PTGER1 and hemorrhagic stroke: Even though our in vitro data demonstrates that EP1 deletion provides neuroprotection against hemin-induced cell death, recently our group has found that EP1 deletion may exacerbate neurobehavioral impairments in a collagenase-induced mouse model of hemorrhagic stroke by impairing the function of microglial cells surrounding the area of injury (Singh et al., 2013).