ADIPOQ and obesity due to melanocortin 4 receptor deficiency: While plasma adiponectin is found at high concentrations in healthy subjects it often correlates negatively with obesity, waist circumference and visceral fat in humans (Arita et al., 1999; Cnop et al., 2003; Ryo et al., 2004; Hanley et al., 2007; Cohen et al., 2011; Mente et al., 2013) and rodents (Maeda et al., 2001; Milan et al., 2002; Delporte et al., 2004; Ye et al., 2007).