Despite the comorbidity of obesity and depression, it is important to note that obese individuals classified as “metabolically healthy,” that is without associated cardiometabolic risk factors (high blood pressure, reduced high-density lipoprotein cholesterol and increased triglycerides, glycated haemoglobin and C-reactive protein), do not appear to have a heightened risk for depression (Hamer et al., 2012). This evidence concerns the gene CRP and major depressive disorder.