However, other reports show that plasma leptin levels are increased in women with depressive disorder (Rubin et al., 2002; Esel et al., 2005; Zeman et al., 2009) and that leptin levels are either increased (Kraus et al., 2002; Esel et al., 2005; Schilling et al., 2013) or not changed (Kraus et al., 2002; Schilling et al., 2013) by antidepressant treatment. The gene discussed is LEP; the disease is depressive disorder.