Figueiredo et al (16) and Wallace et al (17) reported no association between MTHFR 677C>T genotype and long interspersed nuclear element-1 (LINE-1) methylation (a measure of genomic DNA methylation) and ESR1 and SFRP1 methylation, respectively, in the colonic mucosa of 388 subjects with previously resected colorectal adenoma. The gene discussed is SFRP1; the disease is colorectal adenoma.