MTHFR and colorectal cancer: Iacopetta et al (34) measured LINE-1 methylation in the normal mucosa of 178 individuals with colorectal cancer and showed that individuals with the mutant alleles for both MTHFR 677C>T and A1298C (ie, the low-activity genotype 677TT/1298CC) had lower LINE-1 methylation than did those with a high-activity genotype (677CC/1298AA) (P = 0.03).