This analysis demonstrated that 5 of the 12 different proteins significantly identified CRC from the control groups; CEA (P = 0.0003), TFRC (P = 0.0007), MIF (P = 0.0068), OPN/SPP1 (P = 0.0200) and CA242 (P = 0.0090) (Table 2). The gene discussed is CEACAM5; the disease is colorectal carcinoma.