TNFRSF6B and renal cell carcinoma: At the same time, apoptosis (assessed by immunohistochemical detection of cleaved caspase 3) was not induced to a significant extent by LY294002 (data not shown).To further examine a possible association of AKT activation levels and DcR3 expression, we subjected nine pairs of freshly obtained human RCC tissue and adjacent normal renal tissue to immunoblot analysis.