In addition, J Chapuis et al reports IL-33 expression is decreased in Alzheimer’s disease(AD) patients, and confirm that alleles of three SNPs in IL33gene (rs1157505, rs11792633 and rs704343) are associated with AD in Caucasian populations; moreover, genetic variations of IL33 are associated with a lesser degree of CAA, which contains mainly Aβ40, and the local secretion of Aβ40 may be a key determinant of AD pathology[11]. Here, IL33 is linked to early-onset autosomal dominant Alzheimer disease.