Low or absent miR-200c was found in paclitaxel-resistant breast cancer, and the loss of the miR-200c was critical for the acquisition of EMT characteristics mediated by Zinc-finger enhancer binding (ZEB) transcription factors (ZEB1 and ZEB2) [18], which could induce EMT phenotype by suppressing the expression of many epithelial genes including E-cadherin, and form a feedback loop with miR-200 family [95]. Here, ZEB1 is linked to breast cancer.