In univariate analyses, poorer survival after NADC diagnosis was associated with the type of NADC (with those with lung cancer having a much higher mortality rate), male gender, IDU mode of infection, non-white/unknown ethnicity, smoking status, co-infection with HCV or HBV and older age at diagnosis, whereas later year of diagnosis, a higher nadir CD4 count and higher CD4 count at NADC diagnosis were associated with improved survival. The gene discussed is CD4; the disease is infection.