The lymphocytoid portion of the tumor cell clone typically expresses surface IgM in conjunction with pan B cell markers, including CD19 (a B cell receptor [BCR] coreceptor that decreases the threshold for antigen-dependent stimulation of BCR signaling), CD20 (a phosphoprotein that optimizes humoral immune responses to T-independent [TI] antigens), CD22 (a sialic acid-binding, immunoregulatory transmembrane lectin that prevents overactivation of the immune system and development of autoimmunity), and CD79a (an accessory component of the BCR known as Igα). This evidence concerns the gene CD40LG and neoplasm.