MCL can be distinguished from WM based on clinicohistopathologic findings [27] and, in terms of cancer cytogenetics, the almost invariable occurrence of the hallmark t(11;14)(q13;q32) translocation that recombines IGH (Ig heavy-chain locus) on chromosome 14 and CCND1 (cyclin D1) on chromosome 11 [28, 29]. This evidence concerns the gene CCND1 and cancer.