VWF and von Willebrand disease (hereditary or acquired): Since then, several groups have reported the presence of vascular malformation in VWD patients in various localizations, including nail bed,2 skin, prostate and most frequently angiodysplasia of the gastrointestinal tract.3 These lesions can be responsible for severe, intractable bleeding which is often not responsive to VWF replacement therapy and thus represent a significant unmet clinical challenge.