VEGFA and hemangioma: Binding of VEGF-A to VEGF-R2 on EC stimulates dimerization of the receptor and autophosphorylation of specific intracellular tyrosine residues, leading to activation of intracellular signalling cascades, which lead to cell survival, permeability, migration and/or proliferation.14 In vivo, VEGF promotes angiogenesis; however overexpression of VEGF leads to the formation of fragile capillaries, with a disrupted structure, reminiscent of angiomas or angiodysplasia.15,16