ADAMTS13 and Genetic thrombotic microangiopathy: The discovery of the metalloprotease referred to as ADAMTS13 (A Disintegrin-like And Metalloprotease with ThromboSpondin type 1 motif 13), as many other examples in biomedical research, found its way in the attempt to address the issue concerning the pathogenesis of severe forms of thrombotic microangiopathies (TMAs).