In agreement with our results, a recent study indicated that LDL receptor deficient mice C57BL/6 as a mouse model of atherosclerosis fed with saturated fat diet and double knock-out mice (GHSr/ LDL-/-) showed remarkable peak in very low density lipoprotein (VLDL), low density lipoprotein ( LDL ) cholesterol (15). This evidence concerns the gene LDLR and atherosclerosis.