Nutritional rickets was defined as both fulfilling biochemical inclusion criterion, that is, severe vitamin D deficiency (<12.5 nmol/L) or vitamin D deficiency (<25 nmol/L) and at least one other pathological biomarker (raised alkaline phosphatase, raised PTH, or low serum calcium), and clinical and radiological signs, including the effect of the given vitamin D treatment. This evidence concerns the gene PTH and vitamin D deficiency.