Hypoxia, an important stimulus for endothelial cell migration, caused increased MMP-2 release in normal ECFCs but not in IUGR-derived ECFCs (Figure 4A); a direct comparison between pregnancy groups confirmed that the hypoxia-mediated increase in MMP-2 release was greater in normal compared with IUGR-derived ECFCs (Figure 4B). The gene discussed is MMP2; the disease is fetal growth restriction.