CD40 and hemophilia: We found no difference in the percentage of B10 in mice after LV-FIX treatment (n = 3) as compared to saline-injected controls (n = 2) and naive haemophilia B mice (n = 2), both upon a polyclonal (lipopolysaccharide, LPS), or FIX-specific stimulation (anti-CD40 and plate-bound FIX) (Supporting Information Fig S6).