In a SCID mouse model of human xenografted CD30+ anaplastic large-cell lymphoma (ALCL) (JB6 cell line), a 3-day treatment with non-toxic doses of Ber-H2/saporin-S6 (50% of LD50) induced complete remission in 80% of mice when treatment started 24 h after tumor transplantation, and 30% of complete remission when started at a later stage (40–60-mm3 tumor volume) [70]. This evidence concerns the gene TNFRSF8 and anaplastic large cell lymphoma.