One patient with end-stage NHL received a total of 5 mg of saporin-S6 complexed with a pair (50 mg) of anti-CD22 bispecific Abs over 15 days (0, +7, +15), achieving a complete clearance of the tumor from the blood, clearance of the ascites and shrinkage of the tumor masses. This evidence concerns the gene CD22 and non-Hodgkin lymphoma.