Neoplastic tumours are characterised by their absence of differentiation, disrupted apico-basal polarity and their upregulation of Matrix metalloprotease 1 (Mmp1), a target of JNK signalling involved in extracellular matrix remodelling, which is a marker for tumour metastasis (Beaucher et al., 2007; Page-McCaw et al., 2003; Srivastava et al., 2007; Uhlirova and Bohmann, 2006). This evidence concerns the gene MAPK8 and neoplasm.