Unlike most of the endocytic tumour suppressor genes so far identified, Rabaptin-5 has been implicated in human cancers, (Christoforides et al., 2012; Magnusson et al., 2001; Wang et al., 2009; Xiao et al., 1997), and thus the Drosophila mutant may represent a valuable model for the study of human tumourigenesis. Here, RABEP1 is linked to neoplasm.