Crb accumulation is thought to promote the growth aspect of the neoplastic tumour phenotype through misregulation of the Hpo/Wts pathway (Chen et al., 2010; Grzeschik et al., 2010; Ling et al., 2010; Robinson et al., 2010; Robinson and Moberg, 2011). This evidence concerns the gene LATS1 and neoplasm.