MAPK8 and neoplasm: Work in other tumour suppressor mutants in which the phenomenon was first observed, indicates that this probably occurs through a JNK-dependent apoptotic response, which after clone elimination allows tissues to resume their wild-type pattern of growth and development (Agrawal et al., 1995; Brumby and Richardson, 2003; Igaki et al., 2006, 2009; Ohsawa et al., 2011; Uhlirova et al., 2005).