TSC2 and neoplasm: Mammalian Rabaptin-5 controls integrin recycling during migration of invasive tumour cells, has been identified in patients suffering from myelomonocytic leukaemia, is involved in preventing hypoxia in primary kidney and breast tumours and has been shown to interact physically with the Tuberous sclerosis protein Tuberin (Christoforides et al., 2012; Magnusson et al., 2001; Wang et al., 2009; Xiao et al., 1997).