PLD2 and breast carcinoma: Contrarily, it has been hypothesized that PLD2 activity in certain breast cancer cell lines is comparatively low compared to non-cancerous cells or other breast cancer cell lines because it is downregulated by tyrosyl phosphorylation at Y296 via EGF-R (Gomez-Cambronero, 2010), which can also be correlated to a negative impact on the relative levels of cell invasiveness of these breast cancer cells (Foster and Xu, 2003).