Accordingly, the link between circulating ADMA and the degree of IR could be obscured by the inability of plasma ADMA to reflect its intracellular level in endothelial cells, which had previously been suggested by Maas et al. [74] as an explanation for the lack of correlation between plasma ADMA and polymorphisms in the promoter region of the DDAH-2 gene that were related to the prevalence of hypertension. The gene discussed is DDAH2; the disease is hypertensive disorder.