FLG and Alzheimer disease: The study population was divided into four groups: (i) subjects without FLG mutations and with no history of AD (FLG−/AD−); (ii) subjects with FLG mutations but with no history of AD (FLG+/AD−); (iii) subjects without FLG mutations but with a history of AD (FLG−/AD+); and (iv) subjects with both FLG mutations and a history of AD (FLG+/AD+).