GHRL and heart failure: Finally, obestatin measurement in our study did not account for the parallel evaluation of ghrelin, another peptide which originates from the same preprohormone as obestatin and also has a number of beneficial cardiotropic effects: lowering of blood pressure, improving of endothelial function, regulation of atherosclerosis, protection from ischemia-reperfusion injury, and inhibition of myocardial cell apoptosis, as well as improving the prognosis of myocardial infarction and heart failure [6, 8].