ALK and neoplasm: Multiple other tumor types from a wide variety of organ sites have now been found to have different ALK abnormalities, other than NPM-ALK and EML4-ALK fusions, including increased ALK copy number, ALK amplification, ALK gene expression, missense point mutations, fusions between ALK and multiple genes and/or ALK signaling pathway activation (Kelleher and McDermott 2010).