The swelling and enlargement of the breast and the appearance of dimpled skin defined as "peau d’ orange" is associated with the presence of tightly aggregated tumor cells, defined as tumor emboli, that have robust expression of E-cadherin and are encircled by dermal lymphatic vessels (Cristofanilli et al. 2007;Vermeulen et al. 2010). Here, CDH1 is linked to neoplasm.