Though they are usually over-expressed together, our Western blotting analysis of 563 breast tumors from a well-annotated breast tumor repository found a significant discordance in GRB7 and HER-2 protein over-expression, allowing us to investigate the independent prognostic significance of GRB7 protein over-expression in breast cancer (Ramsey et al. [2011]). This evidence concerns the gene ERBB2 and breast cancer.