Previous results of Western analysis (Figure 1a and Additional file 1: Table S1) of primary breast cancer extracts from the OHSU Knight Cancer Institute Breast Cancer Tumor Repository for the presence of GRB7 and HER-2 proteins reported that GRB7 over-expression was found in the absence of HER-2 over-expression in 30 of 564 or 5% of tumors (Ramsey et al. [2011]). This evidence concerns the gene ERBB2 and cancer.