Increased activity of IFN-α has been associated with presence of various SLE-associated autoantibodies, both anti-double-stranded DNA (anti-dsDNA) and anti-RNA-binding protein (anti-RBP) antibodies along with different organ involvement such as hematologic, renal, and central nervous systems (10, 25, 26). Here, IFNA1 is linked to systemic lupus erythematosus.