AASDHPPT and neoplasm: Regardless the many scientific studies published in which peptides are shown to successfully eliminate tumor cells both in vitro and in vivo and also prevent metastases formation (Cruciani et al., 1991; Ellerby et al., 2003; Papo et al., 2003, 2004, 2006), there has always been difficulties in establishing a clear structure-activity relationship for ACPs that might facilitate drug development.