NOP53 and epilepsy: They are also regulated during development and in numbers of physiopathological conditions, including by neuronal activity or epilepsy, via changes in the expression, localization and function of Kir channels and GLT, respectively, and can thus directly affect neighboring synaptic activity and plasticity (Djukic et al., 2007; Tzingounis and Wadiche, 2007; Jabs et al., 2008; Benediktsson et al., 2012).