Increased PICALM transcription levels have been reported in AD (Baig et al. 2010), EEA1 transcription levels have been found to be increased in MCI and AD (Jiang et al. 2010), and Rab4, Rab5 and Rab7 are upregulated in MCI and AD (Jiang et al. 2010; Ginsberg et al. 2010) and abnormally recruited to endosomes in AD (Cataldo et al. 1997, 2000; Yang et al. 2008). This evidence concerns the gene PICALM and Alzheimer disease.