In conclusion, the members of the Japan Society for Gastroenterological Carcinogenesis, investigated the feasibility of a new molecular factor(s) to further supplement the TNM classification system, and found that the combination of VEGF-C and Reg IV might be a promising factor for clinical staging to supplement the classical TNM classification system, and it may suggest a good indication of adjuvant chemotherapy for G2 cases in stage II colorectal cancers. This evidence concerns the gene VEGFC and colorectal cancer.