REG4 and colorectal cancer: Concerning to the positive staining rate of each factor, 51.8% of p53, 59.1% of VEGF-A, 60.0% of VEGF-C, 20.9% of Reg IV, 62.3% of olfactomedin 4, 8.2% of Claudin-18 and 45.5% of MMP-7 were positive in colorectal cancers (Table II).