Similar experiments demonstrated that mice expressing SV40 large T-antigen from the Clara cell-specific CC10 promoter or alveolar type II cell-specific promoter developed early multifocal bronchial alveolar hyperplasia followed by mixed solid and papillary adenocarcinomas to which the mice succumbed by 4–5 months of age (20–22). Here, SCGB1A1 is linked to papillary adenocarcinoma.