MT1G and metastatic malignant neoplasm in the lymph nodes: Similar to univariate analysis, after adjustment, MT1G hypermethylation remained significantly positively associated with lymph node metastasis (OR=2.40, 95% CI=1.19-4.83) (see Additional file 1: Table S4), suggesting that MT1G hypermethylation might be an independent factor in predicting lymph node metastasis for PTC patients.