To explore the molecular mechanism of MT1G contributing to thyroid cancer cell migration and invasion, we investigated the effect of MT1G on expression of E-cadherin and Vimentin, the altered expressions of which are hallmarks of epithelial-mesenchymal transition (EMT) allowing epithelial cells to separate from their neighbors and migrate to distant regions during tumor development [32]. The gene discussed is MT1G; the disease is neoplasm.