Patients with BRCA1 breast tumors tend to have a higher histologic grade, medullary histopathology, and are more likely than sporadic (non-BRCA mutant) tumors to be estrogen receptor negative, progesterone-receptor negative, and HER2/neu overexpression negative or “triple negative” (TNBC) (32). This evidence concerns the gene ERBB2 and breast neoplasm.