The factors included a histological type of osteomyelitis, antibiotic therapy before biopsy, fever (temperature ≥38.0°C), elevated WBC count (≥10×103 L), elevated ESR (≥10 mm/h), elevated CRP (≥6 mg/L), the size of the biopsy needle, and the amount of purulent fluid obtained at biopsy. Here, CRP is linked to osteomyelitis.