Next, we evaluated the role of NLRP3 in host resistance to T. cruzi infection by assessing parasitemia and mortality in NLRP3−/− and caspase-1−/− mice infected with T. cruzi Y. A significantly greater number of T. cruzi parasites were found in the blood of both NLRP3−/− and caspase-1−/− mice compared to WT mice (Figure 2A). This evidence concerns the gene NLRP3 and parasitic infectious disease.