NLRP3 and parasitic infectious disease: T. cruzi activates NLRP3 inflammasome by a mechanism involving cathepsin B. NLRP3−/− and caspase1−/− mice display high parasitemia during acute phase of T. cruzi infection, which could be explained by a severe defect in the production of nitric oxide (NO) and in the impairment of their macrophages to control intracellular parasites.