In our model, the NLRP3−/− and caspase-1−/− mice behaved in a manner identical to the iNOS−/− mice, with a higher magnitude of peak parasitemia compared to WT mice; however, most of the NLRP3−/−, caspase-1−/− and iNOS−/− mice survived infection. This evidence concerns the gene CASP1 and parasitic infectious disease.