INS and cardiovascular disorder: Hence, to gain insights into the molecular events underlying the association between Scd1, fatty liver, and IR, we explored the hepatic expression of Scd1 in two experimental models of HFD-induced NAFLD: Sprague Dawley (SD) rats with increased visceral fat but without IR, and spontaneously hypertensive and IR rats (SHR), a rat model of genetic MS and cardiovascular disease (CVD), in comparison with its normotensive, insulin-sensitive control Wistar-Kyoto (WKY) strain.