Previously, we also reported that circulating progranulin concentration has a significant positive correlation with systemic inflammatory markers such as hsCRP and IL-6 [22] and Yilmaz et al. [23] showed that progranulin is significantly higher in nonalcoholic fatty liver disease patients than in controls, and progranulin expression correlates with the degree of hepatic fibrosis. This evidence concerns the gene IL6 and metabolic dysfunction-associated steatotic liver disease.