IL6 and Hepatic fibrosis: Previously, we also reported that circulating progranulin concentration has a significant positive correlation with systemic inflammatory markers such as hsCRP and IL-6 [22] and Yilmaz et al. [23] showed that progranulin is significantly higher in nonalcoholic fatty liver disease patients than in controls, and progranulin expression correlates with the degree of hepatic fibrosis.