PRKCB and Hyperglycemia: Hyperglycemia can promote vasostatic perfusion deficiency by multiple biochemical abnormalities such as polyol pathway, advanced glycation end products (AGEs), increased oxidative stress, activation of the protein kinase C (PKC)-β pathway and angiogenic factors, resulting in cellular damage such as the vascular endothelium and pericytes, abnormal hemodynamics and autoregulation [49], [50].