CASP3 and fibrosarcoma: However, in the CNS, transient alkalization may follow ischemic acidification events [136]; This alkaline-induced increase in cell death has also been reported for several cell types including human endothelial cells [133], in association with increased activation of caspase-3 pathway and subsequent apoptosis; and a murine fibrosarcoma cell line, in association with elevated Ca+2 and mitochondrial damage [135].