Moreover, in the stratified analysis by HWE in controls, our result indicated a significant association between the MDM2 SNP309 polymorphism and CRC incidence in the studies consistent with HWE (TG vs. TT: OR = 1.166, 95% CI = 1.037–1.311, P= 0.010). This evidence concerns the gene MDM2 and colorectal carcinoma.