We found that the MDM2 SNP309 polymorphism was associated with an increased CRC risk among Asians (TG vs. TT: OR = 1.197, 95% CI = 1.055–1.358, P=0.005; GG+TG vs. TT: OR = 1.246, 95% CI = 1.106–1.404, P=0.000), which was in accordance with the previously published meta-analysis by Cao et al. [12]. This evidence concerns the gene MDM2 and colorectal carcinoma.