A meta-analysis of 8 studies by Cao et al. [12] in 2011 showed that the MDM2 SNP309 polymorphism might be a risk factor for CRC, the variant genotype was associated with a significant increased CRC risk among the overall populations (GT vs. TT: OR=1.19, 95% CI=1.06–1.35) and Asians (GT vs. TT: OR=1.28, 95% CI=1.10–1.50). Here, MDM2 is linked to colorectal carcinoma.