VWF and Pulmonary hemorrhage: In vivo, a single injection of rTM protected mice against histone-induced thrombocytopenia (Figure 6A), VWF-rich intravascular thrombus formation (Figure 6B), dilatation of the right ventricle (Figure 6C-D), pulmonary hemorrhage (Figure S5A in File S1), and death (Figure 6E).