MAP2K1 and malignant colon neoplasm: Zhang et al. demonstrated that miR-23b is down-regulated in human colon cancer and mediates multiple steps of metastasis, including tumor growth, invasion and angiogenesis by regulating a cohort of prometastatic targets, including Frizzled-7 and MAP3K1 (mitogen-activated protein kinase kinase kinase 1) [59].