SFPQ and malignant colon neoplasm: Kurokawa et al. found that miR-19b was up-regulated 3.5-fold in the 5-fluorouracil (5-FU)-resistant colon cancer cells, and potentially regulated the cell cycle regulators, splicing factor proline/glutamate-rich (SFPQ) and v-Mybmyeloblastosis viral oncogene homolog-like 2 (MYBL2) [50].