The four miRNAs regulate PTEN expression post-transcriptionally, and affect the downstream PI3K/Akt pathway via PIK3CA (p110α), PIK3CD (p110δ), PIK3R1 (p85), Akt as well as cyclin D1, thus promote prostate cancer cell proliferation in vitro. The gene discussed is AKT1; the disease is prostate carcinoma.