Zhang et al. demonstrated that miR-23b is down-regulated in human colon cancer and mediates multiple steps of metastasis, including tumor growth, invasion and angiogenesis by regulating a cohort of prometastatic targets, including Frizzled-7 and MAP3K1 (mitogen-activated protein kinase kinase kinase 1) [59]. Here, FZD7 is linked to malignant colon neoplasm.