Flow cytometry analysis in CD71-positive cells showed a strong significant decrease of CD11b expression (Figure 3A) but no significant decrease of CD64, CD16, TLR-2 and TLR-1 expressions (Figure 3C/D/E/F) suggesting a loss of pathogen recognition by CF macrophages involving more specifically CD11b. The gene discussed is FCGR1A; the disease is cystic fibrosis.