In order to determine the specificity of variations observed in CF patients, we analyzed the expression of TLR-5/-4/-1/-2 in non-CF CD71+ macrophages and the IL-1β and TNF-α secretion in the presence of their respective agonists (flagellin, LPS, Pam3CSK4 and LipoTeichoic Acid (LTA)) (Figure S3). The gene discussed is TLR5; the disease is cystic fibrosis.