Moreover, considering the FEV1 values, CF patients with more severe disease (FEV1≤55%, n=7) showed higher but no significant increase of IL-8 secretion (162.9±58.5 pg/ml/106 cells, p=0.08 vs non-CF) than mild disease group (122.9±61.4 pg/ml/106 cells, p=0.288 vs non-CF). This evidence concerns the gene CXCL8 and cystic fibrosis.