Conflicting results have been reported on intracellular SAM contents increasing or decreasing after the knockdown of MAT2A in hepatoma cells [16]–[18], whereas, intracellular SAM contents were increased in all relevant studies after knockdown of MAT2B or both MAT2A and MAT2B [17]–[19]. The gene discussed is MAT2B; the disease is hepatocellular carcinoma.