This could explain our inability to replicate candidate gene (Table 1) associations of SNPs in IRF4 with FL [8], or our observation of weak associations (i.e. a SNP with p<0.05 but that does not pass multiple testing correction) of SNPs in BID, APAF1 and CASP10 with NHL [2]. This evidence concerns the gene APAF1 and non-Hodgkin lymphoma.