CDKN1C and IMAGe syndrome: During the bioinformatic analysis, we were notified of the report by Arboleda et al. [9] describing mutations in CDKN1C in patients with IMAGe syndrome, and subsequently, we identified a non-synonymous A to C SNV with low coverage at position chr11∶2,905,905 in CDKN1C in the three siblings (Figure S1).