CDKN1C and Beckwith-Wiedemann syndrome: Mutations across the length of the CDKN1C gene have been identified in patients with Beckwith-Wiedemann syndrome (BWS), which is characterized by an over-growth phenotype and an association with certain cancers; loss-of-function of CDKN1C promotes cell proliferation giving rise to an over-growth phenotype [11], [12].