Although analysis of TLX1/TLX3-induced T-cell acute lymphoblastic leukemia suggests AML1 is an oncosuppressor [56], overexpression of wt.AML1 promotes the development of mouse T-cell lymphoma [57] and accelerates leukemogenesis in BXH2 mice [49]. The gene discussed is TLX1; the disease is T-cell acute lymphoblastic leukemia.