While enforced expression of wt.AML1 promotes differentiation of mouse hematopoietic cells and compromises engraftment of hematopoietic cells in vivo following transplantation [51], our study shows that wt.AML1 confers upon cells a growth advantage in culture amid BCR-ABL expression, and induces a BC-like phenotype in mice. The gene discussed is ABL1; the disease is breast cancer.