RUNX1 and chronic myelogenous leukemia, BCR-ABL1 positive: In fact, AML1 is the most frequent target gene of chromosomal translocation associated with human leukemia [7], [8], [10], and AML1 point mutations have been often identified in acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and CML-BC [11]–[19].