PRMT5 and melanoma: Overall, the number of samples with ≥5% PRMT5+ cells was significantly higher in malignant (121 of 135 samples PRMT5+) and metastatic (58 of 66 samples PRMT5+) melanoma specimens versus normal epidermis (1 of 21 samples PRMT5+; p<0.0001) (Table 1 and Figure 1A).