In this study, we aimed to investigate relationship between serum ghrelin and four common upper gastrointestinal cancers, namely gastric (non-cardia and cardia) adenocarcinoma, esophageal adenocarcinoma and esophageal squamous cell carcinoma (SCC), all in a population from the Ardabil Province, Iran known to have a high incidence of gastric cancer [16]. The gene discussed is GHRL; the disease is esophageal adenocarcinoma.