Likewise, the continuous variable of ghrelin, scaled to 122 pg/ml, demonstrated a positive relationship between decreasing level of serum ghrelin and gastric cardia cancer, with OR (95 CI%)  = 1.64 (1.25–2.15) and 1.75 (1.24–2.47), before and after adjustment for serum PGI/II ratio, smoking and H.pylori infection status, respectively. This evidence concerns the gene GHRL and gastric cardia carcinoma.