GHRL and esophageal adenocarcinoma: None of the serum ghrelin quintiles were associated with esophageal adenocarcinoma in either univariable or multivariable analysis, but there was marginal inverse relationship seen between decreasing ghrelin level as a continuous variable and risk of esophageal adenocarcinoma, being OR (95% CI) of 0.65 (0.43–1.01) and 0.60 (0.35–1.04) in univariable and multivariable analyses, respectively (Table 4).