Human SCARB2-transgenic mice had been generated by us and proven that they can serve as a reliable infectious model, with the development of severe neurological diseases leading to death upon challenge with EV71 5746-TW98 (C2) or N-3340 (C4) or development of severe HFMD associated with recoverable neurological diseases by E59 (B4) or N2838 (B5) strains [22]. This evidence concerns the gene SCARB2 and nervous system disorder.