Given the association of only 12% DYNLL1 in dynein complex [61], we hypothesized implication of the free form of DYNLL1 in transportation independent processes by inducing an uncontrolled inflammatory response during lung chronic infection of P. aeruginosa, which causes most of the morbidity and mortality in CF patients [62], [63]. This evidence concerns the gene DYNLL1 and Recurrent lower respiratory tract infections.