CD34+ cells from chronic phase CML patients were nucleofected with either mock vector, p27kip1 WT, p27 kip1S10D (cytoplasmic localizing p27kip1) or p27 kip1S10A (nuclear localizing p27kip1) vector. The gene discussed is CDKN1B; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.